Clinical and immunological assessment of a candidate Lyme disease vaccine in healthy adults: antibody persistence and effect of a booster dose at month 12
Identifieur interne : 000247 ( Main/Exploration ); précédent : 000246; suivant : 000248Clinical and immunological assessment of a candidate Lyme disease vaccine in healthy adults: antibody persistence and effect of a booster dose at month 12
Auteurs : C. Van Hoecke [Belgique] ; D. Fu [Belgique] ; D. De Grave [Belgique] ; P. Voet [Belgique] ; E. Lebacq [Belgique]Source :
- Vaccine [ 0264-410X ] ; 1998.
English descriptors
- Teeft :
- Antibody persistence, Antibody response, Antibody titres, Assay, Bactericidal, Bactericidal activity, Bactericidal assay, Bactericidal titres, Blood samples, Booster, Booster dose, Booster dose administration, Borrelia, Borrelia burgdorferi, Borreliacidal activity, Burgdorferi, Diary cards, Elisa, Equivalent antibodies, Equivalent antibody titres, Experimental infection, Gmt, Good correlation, Healthy adults, Human lyme disease vaccine, Immune response, Lyme, Lyme disease, Monoclonal antibodies, Ospa, Primary course, Primary vaccination course, Seropositive, Smithkline beecham biologicals, Spirochete, Surface protein, Titre, Vaccination, Vaccine.
Abstract
Abstract: A candidate Lyme vaccine was administered to 20 adult volunteers following a 0, 1, 2 months vaccination schedule, with a booster at 12 months. An immune response, assessed as ‘LA-2 equivalent’ antibody titres using an inhibition ELISA, was induced in all vaccinees which persisted until the booster. Titres were increased 25-fold following the booster and persisted through month 24. There was a good correlation between ‘LA-2 equivalent’ antibody titres and a bactericidal assay (r2 = 0.86). Local symptoms were mild, resolving spontaneously within 72 h, with no reports of rash, arthralgia or other systemic symptoms. This Lyme vaccine was safe, well-tolerated and elicited an antibody response in all volunteers which persisted at least 12 months after the booster.
Url:
DOI: 10.1016/S0264-410X(98)00052-8
Affiliations:
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An immune response, assessed as ‘LA-2 equivalent’ antibody titres using an inhibition ELISA, was induced in all vaccinees which persisted until the booster. Titres were increased 25-fold following the booster and persisted through month 24. There was a good correlation between ‘LA-2 equivalent’ antibody titres and a bactericidal assay (r2 = 0.86). Local symptoms were mild, resolving spontaneously within 72 h, with no reports of rash, arthralgia or other systemic symptoms. This Lyme vaccine was safe, well-tolerated and elicited an antibody response in all volunteers which persisted at least 12 months after the booster.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Van Hoecke, C" sort="Van Hoecke, C" uniqKey="Van Hoecke C" first="C." last="Van Hoecke">C. Van Hoecke</name></noRegion><name sortKey="De Grave, D" sort="De Grave, D" uniqKey="De Grave D" first="D." last="De Grave">D. De Grave</name><name sortKey="Fu, D" sort="Fu, D" uniqKey="Fu D" first="D." last="Fu">D. Fu</name><name sortKey="Lebacq, E" sort="Lebacq, E" uniqKey="Lebacq E" first="E." last="Lebacq">E. Lebacq</name><name sortKey="Voet, P" sort="Voet, P" uniqKey="Voet P" first="P." last="Voet">P. Voet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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